Healthy longevity for all through scientific research

Major Mouse Testing Program

Click Here to Donate for the Major Mouse Testing Program ! 

Here are the latest slides to download:

  • Coming soon in other langages! (Arabic: thank you Mouad! Dutch: thank you Demian!)
************************************************************************************************************

Here is the Facebook group: https://www.facebook.com/groups/MajorMouseTestingProgram

************************************************************************************************************

Video (October 2014, at the Eurosymposium on Healthy Aging organised by Heales (Healthy Life Extension Society); might be slightly outdated -- the above slides are the reference):

************************************************************************************************************

Project description (might also be slightly outdated -- the slides are the reference, esp in English or French):

Problem
We currently have very little grasp on what is good or harmful on long term health. Human data is starting to be consolidated for such extents, but corresponding knowledge will appear in several decades and current human habbits are very limited compared to what could extend lifespan (e.g. taking rapamycin for years while healthy). Mice offer a fast and cheap approach (in comparison to human clinical trials). So far, about 10% of things that are believed to be good for long term health appear to extend lifespan in mice (7% for a large set of interventions by Dr Spinder's lab, 33% for a very selective set of interventions done by the ITP; the "%" depends on how exploratory the tests are). With the current pace of robust mouse lifespan tests, in about 100 years we may get a sufficient set (eg 100) of interventions that robustly extend mouse lifespan, in order to derive general biological rules/understanding for much larger life extensions.

Solution
This can be accelerated by 10 or more if we test many interventions in parallel (compounds, genetic, other), in large series: THAT is the project. Within about 4 years, about a 100 robust life extending solutions in mice are believed to be found, within another 6 years, adjustement of dosages and combinations should hopefully make "super mice". In addition to allowing a grasp of "what works in mice", "what actually doesn't", "what common pathways extend lifespan", "what could be translated to humans", it should generate a giant mainstream awareness that life extension is happening now: we have the tools for it now, it is a matter of trying what works in humans.

Goal of the project 
To get a number of ways to increase lifespan and healthspan of mice, within a few years -- interventions that could potentially be applied to humans (for example, not a genetic modification since birth). And at least one intervention that shows a strong life extension without strong side effects. To get there... there are a number of milestones to reach.

Few main tasks for the next year

  • Costs must be detailed and attempts to reduce them investigated -- Progress estimated at 50%: various solutions investigated already)
  • A place to perform the experiment will need to be decided -- Progress estimated at 50%: 3 labs and researchers wrodent ith top quality facilities have been identified. We need to get into more details regarding what will 
  • Funds should be found (both might be linked). -- Progress estimated at 5%: A presentation is being finalized to circulate online, with paypal to donate and tax deductions for donors in France and in the USA. Advancing on the other points was needed to get there. Horizon 2020 fundings have been analyzed too and one call could possibly fit (not obvious)
  • The list of interventions to test needs to be investigated carefully, with input from corresponding researchers for every intervention. -- Progress estimated at 25%: sources have been found and looked at carefully by chunks.

The team leader
Edouard Debonneuil

Click Here to Donate for the Major Mouse Testing Program!

Major mouse testing program FAQ