ILA 2016 report

International Longevity Alliance (ILA) – Annual Report for 2016 draft

[[this file will serve to present ILA activities in various places including to outstanding institutions so that they feel more comfortable in their desires and attempts to support longevity research - please add elements that you think are valuable in that regard! All the best for 2017]]

 

Table of contents


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International Longevity Alliance (ILA) – Annual Report for 2016 – draft

Crowdfunding for a senolytics mouse lifespan test

Longevity Month

United States of America

Belgium and the Eurosymposium on Healthy Aging 2016 (EHA) conference, organized by Healthy Life Extension Society (HEALES)

Australia

Israel

Pakistan

Bulgaria

Finland

France

Germany

Russia

Spain and Venezuela

Switzerland

Sweden

Georgia

Ukraine

United Kingdom

Life extension activities around the International Longevity Alliance

Preamble regarding commercial activities : partiality

BioViva

Lifespan.io

Cancer Baseline

Other 1

Other 2

Other 3

Other 4

Articles, presentations and books by ILA members and supporters

ILA board activities

Other

 

 


Crowdfunding for a senolytics mouse lifespan test

 

 

  • At the ILA, it was decided to start a less structured research with one or a series of crowdfundings

    • A specific website was created: http://majormouse.org/

    • It was decided to go through the burgeonning www.Lifespan.io crowdfunding platform

    • Thanks to strong help by Steve Hill and Elena Milova in particular, but also the whole team including and surrounding the ILA board, and Alexandra Stolzing, Josh Mitteldorf and Edouard Debonneuil for the scientific part, a senolytics mouse lifespan test was crowdfunded

    • At the end of 2016, efforts are still being undertaken by Steve and Elena in particular to provide the presents associated with donations, and the experiment is still being adjusted in the Leipzig lab.

    • If all goes well, next crowdfundings may typically mix the senolytics approach with stem cell and/or rejuvenation signal approaches in order to improve the replacement of old tissues by new tissues.

 

 

 


Longevity Month

Like every year since  2013, longevity promotion events have been organized in various places worldwide in October by many like-minded organizations. This year, we reused the 2013 website to mark some evolution and used the following domain name: http://www.longevitymonth.org/ Further organizational and promotional actions associated with this campaign were done at the site Longevity for All http://www.longevityforall.org/longevity-day-and-longevity-month-october-2016/

United States of America

It makes sense to start with this country given the size of the life extension movement there, as represented by its events.



On October 1st and 2nd, the International Conference on Aging and Disease (ICAD) took place at Stanford University, organized by the International Society on Aging and Disease (ISOAD): http://isoad.org/content.aspx?info_lb=606&flag=103

www.isoad.org  

A special panel was held at the conference on “Public support for Aging Research” (contact: Ilia Stambler)

Also, the Movement for Indefinite Life Extension (MILE) produced a promotional video for the desirability and hope of life extension: https://www.youtube.com/watch?v=F2YLnYo5fB4



Picture

Additional smaller promotional events, including dinners and social media postings in honor of the campaign took place in the US.

Belgium and the Eurosymposium on Healthy Aging 2016 (EHA) conference, organized by Healthy Life Extension Society (HEALES)

It makes sense to continue with Belgium given the amplitude and the importance of the ILA in the EHA conference.

 



Third EuroSymposium on Healthy Ageing - a 3 day conference with worldwide biogerontology experts

September 29th - October 1st. Organised by Heales. Special recognition for Didier Coeurnelle and Sven Bulterijs

During that conference, activists wrote and signed The Brussels Declaration for Radical Healthspan Extension to promote a much longer and healthier life everywhere.

http://www.eha-heales.org/declaration.html

 

Didier Coeurnelle, member of the board of the ILA and cochair of Heales was a few time in the media in Belgium to speak about longevity and transhumanism (RTBF Radio, RTL TV,..)

 



Didier Coeurnelle made a TED Talk for the University ULB in Brussels:

 

Staying human by living longer

 

https://www.ted.com/tedx/events/12561

 

The members of Heales meet each month in the Café "A la mort subite" in Brussels.

 

Heales produces each month an electronic newsletter "La mort de la mort"

 

Longevity Dinner on Saturday October 29th

Also in Belgium, an informal meeting of longevity activists took place at Rue de la Longue vie (long life street!:-)) in Brussels, on October 29.

Australia



Avinash K Singh from India Future Society (IFS) and Alyse Sue from Genomix, Australia, organized the 'Longevity Month' event in Sydney on 20th of October, 2016.

https://www.facebook.com/events/1768955290022285/

http://indiafuturesociety.org/

https://www.genomix.co/

 



Also, on October 1st, the Australia-New Zealand Chapter of LongeCity, the worldwide life extension forum, organized an event in Melbourne. Contact: Adam Karlovsky

https://www.facebook.com/events/1563648900598384/

http://www.longecity.org/forum/forum/323-australia-new-zealand/

 

 

Israel



Photo

On line promotions were done by activists of the Israeli Longevity Alliance. This included

- the publication of special articles: http://www.yekum.org/2016/09/

- and promotions on social media, also for the international longevity month campaign as a whole:

https://www.facebook.com/groups/LongevityIsrael/

http://www.longevityisrael.org/

Contact: Ilia Stambler

Nigeria



A seminar was organized by Longevity Nigeria group:

https://www.facebook.com/groups/424397067745808/

Contact: Agbolade Omowole

 

Pakistan

A series of educational meetings and seminars on healthy longevity research and care have been conducted during the Longevity Day and Aging Awareness Month by the Pakistan Aging Research Society (PARS) and the National Academy of Young Scientists (NAYS) in several universities throughout Pakistan — in Lahore, Islamabad, Karachi, Peshawar, Virtual University of Pakistan, and more, with a wide media coverage – raising the awareness about the field at a massive level.

Special thanks to the president of PARS and NAYS, who led this campaign - Aftab Ahmad.

https://www.facebook.com/events/1771101099768374/

https://www.facebook.com/PakistanARS/

 

Bulgaria



Following the Vanguard Scientific Instruments in Management conference, a special declaration was issued by Bulgarian Longevity activists.

Contact: Angel Marchev Sr.

https://www.facebook.com/groups/longevity.alliance/permalink/1155856807834471/

http://vsim-conf.info/en/

Finland

On October 14th, a Longevity Meetup in Helsinki took place as a part of the Longevity Month celebrations.

Contact: Florian Cauvin, Antti Peltonen

https://www.facebook.com/events/972839152826972/

https://www.facebook.com/groups/FinnishLongevityAlliance/

France

Didier Coeurnelle, member of the board of the ILA and cochair of Heales was frequently in the media in France to speak about longevity and transhumanism (France-info télévision, LCI, La chaine parlementaire)

 

Didier Coeurnelle was taking part to events concerning longevity

 

Two small evenings were organized in Paris by Edouard Debonneuil: on October 13th and 29th. One small evening was organized in Nice by Oliver Rowland

PhotoPhoto

Germany

A Life Extension Meetup was organized in Berlin on October 5th by Michael Greve.

https://www.facebook.com/events/1579858935652494/

https://forever-healthy.org/en/

Russia



Picture

On October 1st, the traditional conference “Elderly Patient Care” took place in Moscow in honor of the International Day of Older Persons

http://conf.newdiamed.ru/index.php?m=pb_info

 

On October 14th, an educational seminar was organized by the longevity activists, members of the Life Extension club in the city of Nizhni Novgorod, in Central Russia

https://www.facebook.com/groups/prodleniezhizninn/?hc_ref=PAGES_TIMELINE

Spain and Venezuela



A two-country online exchange was organized: https://youtu.be/oSAZ0l6oiws

Contact: Abelardo Jesus Marquez, Jose Cordeiro

Switzerland



Picture

At the annual Basel Life Science week, Alexander Zhavoronkov had organized a section called “Aging and Drug Discovery forum” where many pharmaceutical companies were present as well a life extensionists. http://www.nature.com/natureevents/science/events/47271-3rd_Annual_International_Aging_Research_for_Drug_Discovery_Forum

 

The Longevity Month Campaign was also supported by the Longevity Switzerland Group at its new website. Contact: Boaz Heller:

http://longevity.ch/event/longevity-day-and-longevity-month-october-2016/

Sweden



A meeting of the Swedish Life Extension Society (Aldrandefonden) was organized. Contact: Linus Petersson.

http://www.aldrandefonden.se/

Georgia



A meeting of the Georgian Longevity Alliance was held. Contact: Jaba Tkemaladze

http://www.longevity.ge/

Russia

 



The Russian ILA team celebrated significant success of promoting R&D in longevity as a high priority of the Government. “Healthy Longevity” was acknowledged as one of the major directions with the National Technological Initiative (NTI).

The target of NTI is to support business development oriented towards the markets of the future that will develop most intensively in the long term up to 2035. The Roadmap of the development of HealthNet (biomedicine) market was approved by the Prime Minister Dmitry Medvedev on the 20 of December, 2017. The Roadmap provisions the development of new therapies to combat and prevent the pathologies of aging, as well as biomarkers of aging.

Daria Khaltourina, ILA Board member, is the coordinator of the Healthy Longevity segment of NTI. This breakthrough event was preceded with persistent advocacy efforts of the Russian longevity activists and researchers.

   

 

Ukraine



Picture

The Museum in honor of the founder of modern gerontological research – Elie Metchnikoff, was opened in Dvurichni, in Kharkov area, as a part of the Longevity Month Campaign, noting Metchnikoff’s foundational contribution to longevity science.

Contact: Ludmila Babai, Olga Berveno dvo-cdyt@yandex.ua

 

Also, a meeting on aging science took place in the Institute of Gerontology, in Kiev. Contact: Anton Kulaga

https://www.facebook.com/groups/immi.portal/

United Kingdom



Picture

A series of H+ longevity prizes were created for the best Longevity Month realizations worldwide: https://hpluspedia.org/wiki/October_2016_Longevity_Month_competition

Contact David Wood, Chris Monteiro

Life extension activities around the International Longevity Alliance

Preamble regarding commercial activities : partiality

The International Longevity Alliance is a not-for-profit organisation that works to promote human life extension through science and technology, with an independent view rather than influenced by money. As such, commercial activities around the ILA or conducted by some of its members have a particular position: the ILA shall not take biased positions with respect to them, however the ILA should support life extension developments. The existence of a large ILA board with scientific expertise, as well a the scientific expertise among the ILA members, including advisory committees and project working groups, alongside different open communication channels (website, facebook groups, skype group, etc.) to exchange on new developments are therefore essential to ensure some level of neutral perception.

 

BioViva

 

Lifespan.io

 

Cancer Baseline

 

 

Other 1

 

 


ILA board meetings

Online meetings took place every other Saturday (with less than five exceptions), including members of the board, members of the ILA and invited members.

 


Articles, presentations, books and conferences outside of October, by ILA members and supporters

Articles

[Both when ILA supporters helped some researcher in publishing, as part of our regular activities, or when they (co)authored the article]

 

Aliper A, Belikov AV, Garazha A, Jellen L, Artemov A, Suntsova M, Ivanova A, Venkova L, Borisov N, Buzdin A, Mamoshina P, Putin E, Swick AG, Moskalev A, Zhavoronkov A. In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state. Aging (Albany NY). 2016 Sep 24;8(9):2127-2152. doi: 10.18632/aging.101047.

 

Aliper A, Plis S, Artemov A, Ulloa A, Mamoshina P, Zhavoronkov A. Deep Learning Applications for Predicting Pharmacological Properties of Drugs and Drug Repurposing Using Transcriptomic Data. Mol Pharm. 2016 Jul 5;13(7):2524-30. doi: 10.1021/acs.molpharmaceut.6b00248.

 

Artcibasova AV, Korzinkin MB, Sorokin MI, Shegay PV, Zhavoronkov AA, Gaifullin N, Alekseev BY, Vorobyev NV, Kuzmin DV, Kaprin АD, Borisov NM, Buzdin AA. MiRImpact, a new bioinformatic method using complete microRNA expression profiles to assess their overall influence on the activity of intracellular molecular pathways. Cell Cycle. 2016;15(5):689-98. doi: 10.1080/15384101.2016.1147633

 

Buzdin AA, Artcibasova AV, Fedorova NF, Suntsova MV, Garazha AV, Sorokin MI, Allina D, Shalatonin M, Borisov NM, Zhavoronkov AA, Kovalchuk I, Kovalchuk O, Kushch AA. Early stage of cytomegalovirus infection suppresses host microRNA expression regulation in human fibroblasts. Cell Cycle. 2016 Dec 16;15(24):3378-3389. doi: 10.1080/15384101.2016.1241928.

 

Kadurin A, Aliper A, Kazennov A, Mamoshina P, Vanhaelen Q, Khrabrov K, Zhavoronkov A. The cornucopia of meaningful leads: Applying deep adversarial autoencoders for new molecule development in oncology. Oncotarget. 2016 Dec 22. doi: 10.18632/oncotarget.14073.

 

Khaltourina D, Korotayev A. Alcohol Control Policies and Alcohol-Related Mortality in Russia: Reply to Razvodovsky and Nemtsov. Alcohol Alcohol. 2016 Sep;51(5):628-9. doi: 10.1093/alcalc/agw022

 

Makarev E, Izumchenko E, Aihara F, Wysocki PT, Zhu Q, Buzdin A, Sidransky D, Zhavoronkov A, Atala A. Common pathway signature in lung and liver fibrosis. Cell Cycle. 2016 Jul 2;15(13):1667-73. doi: 10.1080/15384101.2016.1152435.

 

Mitteldorf J. An epigenetic clock controls aging. Biogerontology. 2016 Feb;17(1):257-65. doi: 10.1007/s10522-015-9617-5.

 

Moskalev A, Zhikrivetskaya S, Shaposhnikov M, Dobrovolskaya E, Gurinovich R, Kuryan O, Pashuk A, Jellen LC, Aliper A, Peregudov A, Zhavoronkov A. Aging Chart: a community resource for rapid exploratory pathway analysis of age-related processes. Nucleic Acids Res. 2016 Jan 4;44(D1):D894-9. doi: 10.1093/nar/gkv1287.

 

Ozerov IV, Lezhnina KV, Izumchenko E, Artemov AV, Medintsev S, Vanhaelen Q, Aliper A, Vijg J, Osipov AN, Labat I, West MD, Buzdin A, Cantor CR, Nikolsky Y, Borisov N, Irincheeva I, Khokhlovich E, Sidransky D, Camargo ML, Zhavoronkov A. In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development. Nat Commun. 2016 Nov 16;7:13427. doi: 10.1038/ncomms13427.

 

Petrov I, Suntsova M, Mutorova O, Sorokin M, Garazha A, Ilnitskaya E, Spirin P, Larin S, Kovalchuk O, Prassolov V, Zhavoronkov A, Roumiantsev A, Buzdin A. Molecular pathway activation features of pediatric acute myeloid leukemia (AML) and acute lymphoblast leukemia (ALL) cells. Aging (Albany NY). 2016 Nov 19;8(11):2936-2947. doi: 10.18632/aging.101102.

 

Pustovalova M, Grekhova A, Astrelina Т, Nikitina V, Dobrovolskaya E, Suchkova Y, Kobzeva I, Usupzhanova D, Vorobyeva N, Samoylov A, Bushmanov A, Ozerov IV, Zhavoronkov A, Leonov S, Klokov D, Osipov AN. Accumulation of spontaneous γH2AX foci in long-term cultured mesenchymal stromal cells. Aging (Albany NY). 2016 Dec 11. doi: 10.18632/aging.101142.

 

Putin E, Mamoshina P, Aliper A, Korzinkin M, Moskalev A, Kolosov A, Ostrovskiy A, Cantor C, Vijg J, Zhavoronkov A. Deep biomarkers of human aging: Application of deep neural networks to biomarker development. Aging (Albany NY). 2016 May;8(5):1021-33. doi: 10.18632/aging.100968.

 

Shepelin D, Korzinkin M, Vanyushina A, Aliper A, Borisov N, Vasilov R, Zhukov N, Sokov D, Prassolov V, Gaifullin N, Zhavoronkov A, Bhullar B, Buzdin A. Molecular pathway activation features linked with transition from normal skin to primary and metastatic melanomas in human. Oncotarget. 2016 Jan 5;7(1):656-70. doi: 10.18632/oncotarget.6394.

 

Vanhaelen Q, Mamoshina P, Aliper AM, Artemov A, Lezhnina K, Ozerov I, Labat I, Zhavoronkov A. Design of efficient computational workflows for in silico drug repurposing. Drug Discov Today. 2016 Sep 28. pii: S1359-6446(16)30343-9. doi: 10.1016/j.drudis.2016.09.019.

 

Yang X, Debonneuil E, Zhavoronkov A, Mishra B. Cancer megafunds with in silico and in vitro validation: accelerating cancer drug discovery via financial engineering without financial crisis. Oncotarget. 2016 Sep 6;7(36):57671-57678. doi: 10.18632/oncotarget.9808.

 

Zhavoronkov A, Kanherkar RR, Izumchenko E, Teka M, Cantor C, Manaye K, Sidransky D, West MD, Makarev E, Csoka AB. Pro-fibrotic pathway activation in trabecular meshwork and lamina cribrosa is the main driving force of glaucoma. Cell Cycle. 2016 Jun 17;15(12):1643-52. doi: 10.1080/15384101.2016.1170261.

Conferences

 

Conference: “Biomedical Innovation for Healthy Longevity”

April 25th-28th, in Saint Petersburg, organized by IVAO: http://ivaoconf.com/

With key people from the field such as Stephen Spindler, Brian Kennedy, Alexander Zhavoronkov, Daria Khaltourina, Matt Kaeberlein, Edouard Debonneuil, Ilia Stambler, and many others.



Elena Milova,

Daria Khaltourina and Edouard Debonneuil

(ILA board members and member close to board)

TEDx at ULB: Staying Human by living longer



https://www.youtube.com/watch?v=py4SuEE9oJ4&t=298s

Didier Coeurnelle, June 2016

Cancer Baseline - 6 month hackathon project with 200 persons